Category: Medicine, Health, & Epidemiology
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Competing Endogenous RNA: A Mechanism for Cancer to Regulate Gene Expression
Competing endogenous RNA (ceRNA) is a post-transcriptional regulatory mechanism that is an emerging focal point in the field of molecular biology. As our knowledge on ceRNA grows, we also uncover tumorigenic exploitations of this mechanism. In this write-up, I’ll explain ceRNA and its role in cancer.
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Linkage Disequilibrium, Human Population Diversity, and the Hemoglobin Gene
Introduction Linkage disequilibrium is a somewhat rudimentary, but effective way to measure of the evolution of a population. It is, essentially, a quantification of the association between alleles (which, in this case, includes single nucleotide variants) as they exist in a population. In a fixed, non-evolving population, there should, theoretically be no association, and all…
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Tracking the Flu with Twitter & Machine Learning
Scraping, geolocating, and classifying tweets to survey cases of the flu.
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Environment vs Inheritance – Air Pollutants Account for More Variation in Gene Expression than Ancestry, Transcriptome Analysis Reveals
Researchers at the Ontario Institute for Cancer Research use RNA-sequence methods to generate transcription profiles of over 1000 French Canadians and find correlations between a number of environmental factors, chiefly air composition.
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Cancer Cells Send MicroRNA In Exosomes to Macrophages, Rewiring Them for Tumorigenesis
Researchers at the National Cancer Institute in Maryland pinpoint miR-1246, a micro RNA, as a potential therapeutic target in mutant p53 colorectal cancers.
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Using Coalescent Analysis to Map the 2016 Zika Virus Outbreak
In this write-up, I’ll retrieve and process Zika genome data, use Bayesian software to generate a Zika gene tree, and propose a route that Zika took to get from Africa to the Americas.
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